IRB activities associated with the VPR-CLS
Ensuring that human subject research be conducted in accordance with ethical and institutional guidelines is essential; however, completing individual state IRB applications for multi-registry linkages can be a time- and resource-intensive endeavor. In an effort to streamline the IRB application and review process, NAACCR and NCI are developing a templated IRB form and exploring the use of a Central IRB for minimal risk cancer registry linkage studies.
One option to help streamline the IRB process is to establish a central IRB that would review multi-site cohort studies and whose review and approval would be accepted by multiple state cancer registries. We are exploring options for a Central IRB dedicated to minimal risk cancer registry linkage studies. Such an IRB would offer a consistent, high quality, and expert review process that would protect privacy and confidentiality while saving time and resources.
A second method to streamline the IRB process is the creation of a Templated IRB Form that would be accepted by multiple states, thereby reducing the amount of time and resources spent completing individual state forms. NAACCR has reviewed state IRB applications and identified common questions to include in the Templated IRB Form. NAACCR will be talking with state registries and IRB’s to determine acceptance of the template. Once participation is determined, an online system would allow researchers to enter common state IRB data elements in a single form that would then be submitted to participating states.